What is Bonac Nucleic Acid?

Definition of Bonac Nucleic Acid

“Bonac Nucleic Acid” is a generic name for a new single-stranded nucleic acid discovered by Bonac. This includes the substances covered by dominant patient as having a specific structure, and this specific structure is in charge of the unique function of Bonac Nucleic Acid.

Nucleic acid is a component essential to the body. However, since nucleic acid must be digested and metabolized for use in the body, it is immediately degraded in the body and therefore is unstable. Bonac Nucleic Acid is made from a natural form of nucleic acid, however it is resistant to degradation due to its characteristic structure and can be delivered in a stable manner to the area of the body that requires the drug. Also, since Bonac Nucleic Acid is made from a natural form of nucleic acid, it is considered safe to the body.

Due to the design of the internal sequence in Bonac Nucleic Acid, a similar effect to siRNA and miRNA can be obtained. We are also continuing to meet challenges in new areas where the technology of Bonac Nucleic Acid can be utilized.

Classification of Bonac Nucleic Acid

Bonac Nucleic Acid has different shapes and functions depending on the functionality given.

Structure of Bonac Nucleic Acid

Bonac Nucleic Acid

ボナック核酸
  • Single-stranded nucleic acid with chain length not less than 50 bases
  • Unique secondary structure due to self-annealing, and annealing process is not required
  • Devised not only nucleic molecules but also unique hybrid molecule (PnkRNA) with unique amino acid amidite (ingredient for nucleic acid)
  • Higher stability compared to traditional method
  • Does not trigger immune response

Traditional RNA

siRNA
  • Double-stranded nucleic acid with each chain consisting of not more than 49 bases
  • Requires annealing process
  • Susceptible to degradation and measures must be taken to stabilize
  • May trigger immune response

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