Synthesis of nucleic acid

Development of original ingredient


Bonac has developed “amidite,” which is an ingredient for nucleic acid medicine.

This original ingredient “amidite” enables the synthesis of long-chain RNA, the characteristic of Bonac Nucleic Acid. In addition, we have developed “amino acid amidite,” which enables the introduction of amino acid as a biological component in nucleic acid.

We utilize biological components in this manner because we consider safety in the body to be of the highest importance from the stage of ingredient development.

TBDMS amidite

TBDMS amidite

RNA amidite used most widely around the world

BONAC amidite

BONAC amidite

Unique RNA amidite developed by Bonac which enables efficient synthesis of long-chain RNA

Highly efficient synthesis of nucleic acid

RNA synthesis using generally available amidite, and the issues which arise

When TBDMS amidite is used, connection of 62 bases is extremely difficult, with 16% efficiency in synthesis.

RNA synthesis using Bonac Amidite

When Bonac Amidite is used, 62 bases can be connected easily, with 84% efficiency in synthesis.

Development of conjugate nucleic acid

In order to complete Bonac Nucleic Acid as a pharmaceutical product, the nucleic acid must be delivered efficiently and specifically to the target cells in the affected area. In order to achieve this, Bonac is currently developing new conjugate nucleic acids.

These new Bonac Nucleic Acids enable modification not only at the 5’ terminal or 3’ terminal in the previous products, but also enable modification inside the long-chain RNA with functional molecules. We have established the method for synthesis of conjugate nucleic acids with the binding of functional molecules shown in the figure below, with high yield and high purity.